Arthritis Profile and test

Arthritis is a common condition that causes joint inflammation, pain, and stiffness. It can affect people of all ages, including children.

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ANA SCREENING (IMMUNOFLUORESCENCE)
An ANA (antinuclear antibody) test using immunofluorescence measures the presence and amount of antinuclear antibodies in the blood, which can indicate an overactive immune system and potentially autoimmune diseases. The test results are reported as a titer (a measure of the antibody level) and a staining pattern.

Here’s a more detailed explanation:

What is an ANA test?

Purpose:

The ANA test is a blood test that detects antinuclear antibodies (ANAs) in the blood.

What are ANAs?

ANAs are antibodies that mistakenly target the nucleus of the body’s own cells, potentially leading to inflammation and autoimmune conditions.

How it works:

The test typically uses an indirect immunofluorescence assay (IFA), where a sample of your blood is mixed with a fluorescent dye-labeled antibody that binds to the ANAs, if present.

What the test measures:

The test measures the level of ANAs in your blood, which is reported as a titer.

Why is it important?

A positive ANA test can suggest an autoimmune disorder, but it’s not a definitive diagnosis and further testing is often needed.

What does the ANA titer mean?

Titer:

The titer is a measure of the amount of ANAs in your blood, expressed as a ratio (e.g., 1:40, 1:80, 1:160).

Higher titer:

A higher titer indicates a greater amount of ANAs, which may be more indicative of an autoimmune condition.

Normal vs. Abnormal:

While some healthy individuals may have low levels of ANAs, a high titer is more likely to suggest an autoimmune disorder.

Cutoff:

Some labs may consider a titer above a certain level (e.g., 1:160) as positive, but this can vary.

What are the staining patterns?

Besides the titer, the test also identifies a staining pattern:

This pattern describes how the fluorescent dye binds to the cell nuclei, which can provide clues about the type of autoimmune condition.

Common patterns:

Some common patterns include homogeneous, speckled, centromere, and others.

When is an ANA test ordered?

Symptoms:

Your doctor may order an ANA test if you have symptoms of an autoimmune disease, such as fatigue, joint pain, skin rashes, or other symptoms.

Autoimmune disorders:

ANA tests are often used to help diagnose autoimmune diseases like Systemic Lupus Erythematosus (SLE or lupus), Rheumatoid Arthritis, and other connective tissue disorders.
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ANTI CYCLIC CITRULLINATED PEPTIDE; ANTI CCP
About this package

Anti-Cyclic Citrullinated Peptide is an antibody found to be present in individuals with rheumatoid arthritis (RA). Measuring its levels helps in detecting as well as assessing the severity of RA. This test is available at an affordable price with home collection services.

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Anti-cyclic citrullinated peptide (CCP) is a blood test that screens for antibodies that attack healthy cells. It’s a common diagnostic tool for rheumatoid arthritis (RA).

What is it used for?

To diagnose or rule out RA

To predict the severity of RA

To monitor patients with inflammatory polyarthritis (IP)

What are the symptoms of RA?

Joint pain, especially in the morning

Joint stiffness

Joint swelling

Fatigue

Low-grade fever

What are the results of the test?

Negative: Less than 20 EU/mL

Weakly positive: 20–39 EU/mL

Moderately positive: 40–59 EU/mL

Strongly positive: More than 59 EU/mL

What else can cause a positive result? Systemic lupus erythematosus (SLE), Familial Mediterranean fever, Behçet’s disease, and Psoriatic arthritis.

Other information

CCP antibodies are a type of autoantibody

CCP antibody tests are often done with rheumatoid factor (RF) tests

CCP antibody testing results may be available within a few business days
Original price was: ₹1,870.00.Current price is: ₹1,800.00.

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ANTI NUCLEAR ANTIBODIES (ANA)
About this package

ANAs are a special class of autoantibodies that bind and destroy certain parts in the nucleus of the cell. Although a little amount of ANA is found in the normal population, an increased level is normally observed in people with connective tissue disease (CTD). Book ANA test at an affordable price, with a free home collection from Thyrocare.

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Antinuclear antibodies (ANA) are autoantibodies that bind to components within the cell nucleus, and a positive ANA test can indicate an autoimmune condition, though it’s not specific for any particular disease.

Here’s a more detailed explanation:

What are ANAs?

ANAs are a type of autoantibody, meaning they are antibodies that your immune system mistakenly produces against your own body’s tissues.

What do they target?

Specifically, ANAs target the cell nucleus, which contains DNA and other important components.

Why are they important?

A positive ANA test can be a sign of an autoimmune disease, where the immune system attacks healthy cells and tissues.

What diseases are they associated with?

ANAs are often associated with autoimmune diseases like systemic lupus erythematosus (SLE), Sjögren’s syndrome, and systemic sclerosis (SSc), among others.

What is the ANA test?

The ANA test is a blood test that looks for the presence and amount of antinuclear antibodies in your blood.

What does a positive ANA test mean?

A positive ANA test means that the test detected a higher-than-normal level of antinuclear antibodies in your blood.

What are the next steps?

A positive ANA test may indicate a need for follow up blood tests, physical exam, and a review of history and symptoms.

Is a positive ANA test always a sign of an autoimmune disease?

No, not always. Many healthy individuals can have detectable levels of ANAs, and the presence of ANAs alone doesn’t necessarily mean you have an autoimmune disease.

How is the ANA test used?

The ANA test is used as a screening tool for autoimmune diseases, but it’s important to note that a positive ANA test doesn’t confirm a specific diagnosis.

What are the next steps if you have a positive ANA test?

If you have a positive ANA test, your doctor may order further tests to help determine the cause of the elevated ANA levels and to rule out or confirm specific autoimmune diseases.

What are some other tests that may be ordered?

These tests may include tests for specific antibodies, blood tests for inflammation, and a physical exam.
Original price was: ₹850.00.Current price is: ₹800.00.

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ANTI NUCLEAR ANTIBODY / FACTOR (ANA/ANF), EIA
Antinuclear antibodies (ANA) are a type of antibody that can indicate autoimmune disorders. The ANA test is a blood test that measures the amount of ANA in your blood.

What is ANA?

ANA are a type of autoantibody that bind to the nucleus of cells

The nucleus is responsible for sending signals that control cell functions

ANA are a defining feature of autoimmune connective tissue disease

What conditions are associated with ANA? Systemic lupus erythematosus (SLE), Sjogren’s syndrome, Polymyositis/dermatomyositis, and Rheumatoid arthritis.

How is the ANA test performed?

The ANA test can be performed using indirect immunofluorescence (IIF) or solid-phase assays

The IIF technique is the most common method used to detect ANA

The ANA test measures the titer of ANA, which is the amount of autoantibodies in the blood

What do the results mean?

A positive ANA test indicates the presence of autoantibodies, but it doesn’t necessarily mean you have an autoimmune disease

A high titer of ANA is characteristic of people with connective tissue disorders
Original price was: ₹825.00.Current price is: ₹800.00.

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ANTINUCLEAR ANTIBODIES-17 BLOT(Immunoblot)
An antinuclear antibodies (ANA) 17 blot test, also known as an ANA-17 Pro test, is a blood test used to detect autoantibodies that target specific antigens within the cell nucleus, helping diagnose and differentiate between various autoimmune diseases.

Here’s a more detailed explanation:

What it is:

ANA Blot 17 antigens test:

This test detects the presence of antinuclear antibodies (ANAs) in the blood, which are autoantibodies that the body produces that attack its own healthy cells.

Purpose:

It helps diagnose and differentiate between various autoimmune diseases, including systemic lupus erythematosus (SLE), Sjogren’s syndrome, mixed connective tissue disease (MCTD), scleroderma, and others.

How it works:

The test uses a strip with 17 specific antigens, allowing for the identification of antibodies against these antigens, which can help determine the type of autoimmune condition.

Antigens:

The test detects antibodies against antigens like dsDNA, nucleosomes, histones, rib, SS-A, Ro-52, Scl-70, and PM-Scl.

Interpretation:

A positive result indicates the presence of ANAs, suggesting a possible autoimmune disease.

Why it’s done:

Diagnosis:

To help diagnose autoimmune diseases when symptoms like joint pain, fatigue, fever, and skin rashes are present.

Confirmation:

To confirm a diagnosis after a preliminary ANA screening test (like ANA IFA or ELISA) is positive.

Differentiation:

To help differentiate between different autoimmune conditions based on the specific antibodies detected.

Important Considerations:

Positive Results:

A positive ANA test result doesn’t necessarily mean you have an autoimmune disease, as many healthy individuals also have ANAs in their blood.

Further Testing:

A positive ANA test often requires further testing to determine the specific type of autoimmune disease and the severity of the condition.

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Original price was: ₹3,630.00.Current price is: ₹3,500.00.

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27%
ARTHRITIS PROFILE
An arthritis profile is a series of blood tests used to help diagnose and assess arthritis, focusing on inflammatory markers and autoimmune activity. It can help determine the type and severity of arthritis and guide treatment plans.

Here’s a more detailed explanation:

Purpose:

The arthritis profile helps doctors understand the underlying causes of arthritis, differentiate between different types (like rheumatoid arthritis and osteoarthritis), and monitor the effectiveness of treatment.

Tests Included:

Common tests in an arthritis profile include:

C-reactive protein (CRP): A marker of inflammation in the body.

Erythrocyte sedimentation rate (ESR): Another marker of inflammation.

Rheumatoid factor (RF): A protein found in the blood of people with rheumatoid arthritis.

Anti-CCP antibodies: A type of autoantibody found in people with rheumatoid arthritis.

Antinuclear antibodies (ANA): Autoantibodies that can be elevated in various autoimmune conditions.

Complete blood count (CBC): A general blood test that can reveal signs of inflammation or infection.

Uric acid: Elevated levels can indicate gout, a type of arthritis.

Antistreptolysin O (ASO): An antibody that can be elevated after a streptococcal infection, which can sometimes trigger arthritis.

How it’s done:

The arthritis profile is typically a blood test, but may also include a urine sample.

Interpreting Results:

Elevated levels of inflammatory markers (CRP, ESR) or the presence of certain autoantibodies (RF, anti-CCP) can suggest arthritis or other autoimmune conditions.

Types of Arthritis:

The tests can help differentiate between different types of arthritis, such as rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and other inflammatory conditions.
Original price was: ₹4,850.00.Current price is: ₹3,500.00.

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ARTHRITIS PROFILE – A

Arthritic disorders affect majority of the population, varying in severity. Many of these disorders are self limiting conditions requiring minimal evaluation and symptomatic therapy. However several patients show persistent musculo-skeletal symptoms that requires laboratory testing to establish diagnosis and document the pathological process. Complement mediated immune complex deposition may also result in arthritic changes.

Original price was: ₹3,409.00.Current price is: ₹3,000.00.

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ARTHRITIS PROFILE – B
An Arthritis Profile – B test is a blood test panel that helps assess inflammation and identify potential causes of arthritis, including rheumatoid arthritis, by analyzing markers like ESR, CRP, rheumatoid factor (RF), and anti-CCP.

Here’s a more detailed explanation:

What it tests for:

Erythrocyte Sedimentation Rate (ESR): Measures how quickly red blood cells settle in a tube, indicating inflammation.

C-Reactive Protein (CRP): A protein released by the liver during inflammation, indicating the body’s inflammatory response.

Rheumatoid Factor (RF): An antibody found in some people with rheumatoid arthritis.

Anti-CCP (Anti-Cyclic Citrullinated Peptide): Another antibody that can be a marker for rheumatoid arthritis.

Complete Blood Count (CBC): Provides a general overview of blood cell counts, which can help identify other potential issues.

ANA (if): This blood test helps detect presence of antinuclear antibodies (ANA) in blood that attack components of cells and lead to inflammation

Serum calcium, 24-hour urine phosphorus, serum urea acid, dihydroxyvitamin D

Why it’s important:

Diagnosis: Helps doctors determine if someone has arthritis or other inflammatory conditions.

Monitoring: Can track the progression of arthritis and the effectiveness of treatment.

Identifying the type of arthritis: Helps differentiate between different types of arthritis, such as rheumatoid arthritis and osteoarthritis.

Assessing inflammation: Helps determine the severity of inflammation in the body.
Original price was: ₹5,441.00.Current price is: ₹4,800.00.

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ARTHRITIS PROFILE ADVANCED

Arthritic disorders affect majority of the population, varying in severity. Many of these disorders are self limiting conditions requiring minimal evaluation and symptomatic therapy. However several patients show persistent musculo-skeletal symptoms that requires laboratory testing to establish diagnosis and document the pathological process. Complement mediated immune complex deposition may also result in arthritic changes.

Original price was: ₹4,532.00.Current price is: ₹4,000.00.

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BONE PROFILE – ADVANCED
A bone profile blood test assesses bone health by measuring levels of key minerals, proteins, and enzymes in the blood, providing insights into bone turnover, mineral balance, and overall skeletal health.

Here’s a more detailed explanation:

What a Bone Profile Measures:

Calcium:

Essential for bone health, nerve function, and muscle contraction.

Phosphate:

Works with calcium to maintain bone health and is crucial for energy production and cell function.

Alkaline Phosphatase (ALP):

An enzyme produced by osteoblasts during bone formation; elevated levels can indicate increased bone turnover or bone growth.

Albumin:

A protein created in the liver, low levels are associated with lower bone density.

Other markers:

Depending on the specific test, a bone profile may also include markers like osteocalcin (a protein produced by osteoblasts during bone formation).

Why Bone Profile Tests are Important:

Diagnosis:

Bone profile tests can help diagnose and monitor conditions like osteoporosis, Paget’s disease of the bone, and other bone disorders.

Monitoring Bone Health:

They can track bone turnover and mineral balance, helping healthcare professionals assess the overall health of the skeleton.

Evaluating Metabolic Processes:

The test helps determine how well the body’s metabolic processes are affecting the skeleton.

Assessing Bone Density:

A bone density scan (DEXA scan) is often used alongside a bone profile to assess bone strength and density.

When a Bone Profile Test Might Be Recommended:

Osteoporosis Risk Factors:

Individuals with a family history of osteoporosis, those who have experienced fractures, or those who are at risk due to age or other factors may be recommended for a bone profile.

Suspected Bone Disorders:

If someone has symptoms or signs of bone problems, such as pain, fractures, or changes in bone density, a bone profile might be ordered.

Monitoring Treatment:

Bone profile tests can be used to monitor the effectiveness of treatments for bone disorders.

Other Conditions:

Bone profile tests can also be used to assess conditions that affect bone health, such as kidney problems, liver disease, or hormone imbalances.
Original price was: ₹3,250.00.Current price is: ₹3,200.00.

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BONE PROFILE – BASIC
A bone profile blood test assesses bone health by measuring levels of key minerals, proteins, and enzymes in the blood, providing insights into bone turnover, mineral balance, and overall skeletal health.

Here’s a more detailed explanation:

What a Bone Profile Measures:

Calcium:

Essential for bone health, nerve function, and muscle contraction.

Phosphate:

Works with calcium to maintain bone health and is crucial for energy production and cell function.

Alkaline Phosphatase (ALP):

An enzyme produced by osteoblasts during bone formation; elevated levels can indicate increased bone turnover or bone growth.

Albumin:

A protein created in the liver, low levels are associated with lower bone density.

Other markers:

Depending on the specific test, a bone profile may also include markers like osteocalcin (a protein produced by osteoblasts during bone formation).

Why Bone Profile Tests are Important:

Diagnosis:

Bone profile tests can help diagnose and monitor conditions like osteoporosis, Paget’s disease of the bone, and other bone disorders.

Monitoring Bone Health:

They can track bone turnover and mineral balance, helping healthcare professionals assess the overall health of the skeleton.

Evaluating Metabolic Processes:

The test helps determine how well the body’s metabolic processes are affecting the skeleton.

Assessing Bone Density:

A bone density scan (DEXA scan) is often used alongside a bone profile to assess bone strength and density.

When a Bone Profile Test Might Be Recommended:

Osteoporosis Risk Factors:

Individuals with a family history of osteoporosis, those who have experienced fractures, or those who are at risk due to age or other factors may be recommended for a bone profile.

Suspected Bone Disorders:

If someone has symptoms or signs of bone problems, such as pain, fractures, or changes in bone density, a bone profile might be ordered.

Monitoring Treatment:

Bone profile tests can be used to monitor the effectiveness of treatments for bone disorders.

Other Conditions:

Bone profile tests can also be used to assess conditions that affect bone health, such as kidney problems, liver disease, or hormone imbalances.
Original price was: ₹2,250.00.Current price is: ₹2,200.00.

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COLLAGEN DISEASE ANTIBODIES PANEL

The essential features of autoimmune diseases is that tissue injury is caused by immunologic reaction of the organism against its own tissues. These abnormal responses are usually triggered by bacterial or viral infections, smoking or endogenous abnormalities in the immune system. This autoimmune process can be antibody mediated or cell mediated and manifests in a large number of pathologic conditions.

Original price was: ₹9,700.00.Current price is: ₹9,000.00.

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HLA-B27 FLOW CYTOMETRY
About this package

Human Leukocyte antigen B27 (HLA- B27) belongs to a group of cell surface glycoproteins which are expressed on most nucleated human cells and platelets. It is a major histocompatibility complex (MHC) class I molecule. The presence of HLA – B27 is strongly associated with ankylosing spondylitis and some inflammatory disorders like Reiter’s syndrome, inflammatory bowel syndrome, etc. The binding ability of specific monoclonal antibodies to the antigenic determinants expressed by leucocytes on the surface forms the basis of this test. HLA-B 27 test is generally advised in patients suffering from joint pain where the diagnosis of ankylosing spondylitis is suspected. A positive test result indicates higher chances of developing this disease. Avail of the service by booking the HLA-B27 test online at an affordable rate, at your doorstep.

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HLA-B27 is a protein found on white blood cells that helps the immune system identify harmful substances. It’s also the name of a blood test that checks for the presence of this protein.

What is HLA-B27 associated with?

Ankylosing spondylitis: An autoimmune disease that affects the spine. Most people with ankylosing spondylitis have the HLA-B27 gene, but many people with the gene never develop the disease.

Reactive arthritis: An autoimmune disease that affects the joints. 60–85% of patients with reactive arthritis are HLA-B27 positive.

Juvenile arthritis: An autoimmune disease that occurs in children.

How is the test performed?

The HLA-B27 test is a blood draw that’s usually taken from the arm.

A healthcare provider in a doctor’s office or a clinical lab administers the test.

The blood is collected in a tube and sent to a lab for analysis.

HLA-B27 prevalence

The prevalence of HLA-B27 varies between populations.

In the UK, HLA-B27 is present in 90–95% of patients with ankylosing spondylitis.

In the general population, 8 in every 100 people have the HLA-B27 gene variant.
Original price was: ₹2,299.00.Current price is: ₹2,200.00.

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RHEUMATOID ARTHRITIS PANEL

Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology marked by a symmetric, peripheral polyarthritis. Serum antibodies to Cyclic citrullinated peptides (Anti CCP) are now recognised to be a valuable marker of diagnostic and prognostic significance. ANA’s occur both in systemic and organ specific autoimmune diseases showing positivity in Rheumatoid arthritis.There is incremental value in testing for presence of both Rheumatoid factor (RF) and Anti CCP as some patients with RA are positive for RF but negative for Anti CCP and vice versa.

Original price was: ₹3,100.00.Current price is: ₹3,000.00.

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RHEUMATOID AUTOIMMUNE COMPREHENSIVE PANEL

Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology marked by a symmetric, peripheral polyarthritis. Being a systemic disease, RA can result in a variety of extra-articular manifestations. ANA’s occur both in systemic and organ specific autoimmune disease showing positivity in Rheumatoid arthritis, Scleroderma, Sjogren’s syndrome, Mixed connective tissue disease and CREST syndrome

Original price was: ₹10,800.00.Current price is: ₹9,500.00.

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RHEUMATOID AUTOIMMUNE PANEL

Rheumatoid arthritis (RA) is a chronic inflammatory disease of unknown etiology marked by a symmetric, peripheral polyarthritis. Being a systemic disease, RA can result in a variety of extra-articular manifestations. ANA’s occur both in systemic and organ specific autoimmune disease showing positivity in Rheumatoid arthritis, Scleroderma, Sjogren’s syndrome, Mixed connective tissue disease and CREST syndrome

Original price was: ₹6,200.00.Current price is: ₹6,000.00.

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