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1,25-Dihydroxy vitamin D plays a primary role in the maintenance of calcium homeostasis. A part of circulating 25-hydroxy vitamin D is converted to 1, 25-dihydroxy form in the kidneys. Patients who present with hypercalcemia, hyperphosphatemia and low PTH may suffer from unregulated conversion of vitamin D from mono-hydroxy to dihydroxy form as is seen in granulomatous diseases like Sarcoidosis and nutritionally induced Hypervitaminosis D.
The clinical syndrome of Vitamin D deficiency can be a result of deficient production in the skin, lack of dietary intake, accelerated losses, impaired vitamin D activation or resistance to the biologic effects of vitamin D. In addition intestinal malabsorption of dietary fat leads to Vitamin D deficiency which is further exacerbated in the presence of terminal ileal disease. Vitamin D also helps in the homeostatic mechanisms of calcium, phosphorus and alkaline phosphatase.
The clinical syndrome of Vitamin D deficiency can be a result of deficient production in the skin, lack of dietary intake, accelerated losses, impaired vitamin D activation or resistance to the biologic effects of vitamin D. In addition intestinal malabsorption of dietary fat leads to Vitamin D deficiency which is further exacerbated in the presence of terminal ileal disease. Intestinal calcium absorption is also controlled by vitamin D.
Deficiencies of vitamin D or vitamin B12 cause mild chronic ailments and serious diseases. Eating a well-balanced diet might not provide enough of these vitamins for individual needs. Vitamin B12 deficiencies often result from restricted diets & modern lifestyles which limit exposure to sunlight also reduce the amount of vitamin D.
The clinical syndrome of Vitamin D deficiency can be a result of deficient production in the skin, lack of dietary intake, accelerated losses, impaired vitamin D activation or resistance to the biologic effects of vitamin D. In addition intestinal malabsorption of dietary fat leads to Vitamin D deficiency which is further exacerbated in the presence of terminal ileal disease. Intestinal calcium absorption is also controlled by vitamin D.
Vitamin E helps in the maintenance of biomembranes of vascular and nervous systems & has anti-oxidant properties. This assay is useful for evaluating individuals with motor and sensory neuropathies. It is also useful for monitoring vitamin E status of premature infants requiring oxygenation. It is a useful test in persons with intestinal malabsorption of lipids.
Vitamins are essential constituents of human diet since either they are synthesized inadequately or not at all in human body. Vitamin deficiencies affect all ages, the groups most susceptible to deficiencies are pregnant and lactating women, young children because of relatively high need, chronically ill patients and alcoholics. After gastric bypass surgery patients are at high risk of multiple vitamin deficiencies. Conversely, because of widespread use of nutrient supplements, nutrient toxicities are also gaining pathophysiological and clinical importance. Laboratory investigations play an important role in detecting subclinical deficiencies as well as probable toxicities in asymptomatic patients.
About this package
The Winter Wellness Package with Vitamins is an essential diagnostic package to protect your health throughout the winter season. This profile includes 101 tests that assess vital health parameters to detect potential issues early. It offers insights into your liver, kidney, heart, diabetes, thyroid and more—all in a single test. Additionally, it evaluates electrolytes, iron levels and essential vitamins to keep you healthy during winter. Get FREE home collection services with reports within 6 hours* of samples reaching the lab – live tracking of reports available too.
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