Trichomonas vaginalis is a parasitic protozoan that causes trichomoniasis, a common sexually transmitted infection (STI). It’s a flagellated, anaerobic parasite that infects the urogenital tract.
Key points about Trichomonas vaginalis:
Causative Agent:Trichomonas vaginalis is the sole causative agent of trichomoniasis.
Transmission:It’s primarily transmitted through sexual contact, including vaginal, oral, and anal sex.
Incubation Period:The incubation period for trichomoniasis is typically 5 to 28 days.
Symptoms:While many people are asymptomatic, symptoms in women can include vaginal discharge, itching, painful intercourse, and urinary symptoms. Men may experience urethritis, testicular pain, or penile discharge.
Treatment:Trichomoniasis is easily treated with antibiotics like metronidazole or tinidazole.
Complications:Untreated trichomoniasis can increase the risk of acquiring or transmitting other STIs, including HIV, and can also cause inflammation of the reproductive tract.
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Tumor necrosis factor (TNF)-alpha is expressed primarily by activated monocytes as part of the innate immune response to various microbes, gram-negative bacteria in particular. It’s function is to recruit other leukocytes to the site of infection and to stimulate their activation. TNF-alpha also has some systemic effects, including induction of fever through action on the hypothalamus. In cases of severe gram-negative bacterial infection, Septic shock can occur characterized by hypotension, disseminated intravascular coagulation, tachycardia & increased respiration and can be fatal. Dysregulation of TNF-alpha expression is thought to be a critical pathogenic mechanism in numerous autoimmune diseases, including Inflammatory bowel disease (IBD), Rheumatoid arthritis (RA) and Ankylosing spondylitis (AS). TNF-alpha is used for the evaluation of patients with suspected systemic infection, particularly caused by gram-negative bacteria & for the evaluation of patients with suspected chronic inflammatory disorders.
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