An anti-thyroglobulin antibody test measures the amount of antibodies in the blood that target the thyroglobulin protein. This test can help detect thyroid problems.
What is thyroglobulin?
Thyroglobulin is a protein produced by the thyroid gland.
It helps make the thyroid hormones thyroxine (T4) and triiodothyronine (T3).
A small amount of thyroglobulin leaks into the bloodstream.
Why is the test done?
The test can help detect thyroid problems like thyroiditis, Hashimoto’s thyroiditis, and Grave’s disease.
It can also help monitor patients with thyroid cancer.
What can the test results mean?
High levels of thyroglobulin antibodies can indicate thyroid damage, an autoimmune condition, or thyroid cancer.
Declining levels may indicate reduced tumor burden or the absence of disease.
How is the test performed?
A healthcare professional draws blood from a vein in your arm.
The blood sample is then sent to a lab for analysis.
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An antinuclear antibodies (ANA) 17 blot test, also known as an ANA-17 Pro test, is a blood test used to detect autoantibodies that target specific antigens within the cell nucleus, helping diagnose and differentiate between various autoimmune diseases.
Here’s a more detailed explanation:
What it is:
ANA Blot 17 antigens test:
This test detects the presence of antinuclear antibodies (ANAs) in the blood, which are autoantibodies that the body produces that attack its own healthy cells.
Purpose:
It helps diagnose and differentiate between various autoimmune diseases, including systemic lupus erythematosus (SLE), Sjogren’s syndrome, mixed connective tissue disease (MCTD), scleroderma, and others.
How it works:
The test uses a strip with 17 specific antigens, allowing for the identification of antibodies against these antigens, which can help determine the type of autoimmune condition.
Antigens:
The test detects antibodies against antigens like dsDNA, nucleosomes, histones, rib, SS-A, Ro-52, Scl-70, and PM-Scl.
Interpretation:
A positive result indicates the presence of ANAs, suggesting a possible autoimmune disease.
Why it’s done:
Diagnosis:
To help diagnose autoimmune diseases when symptoms like joint pain, fatigue, fever, and skin rashes are present.
Confirmation:
To confirm a diagnosis after a preliminary ANA screening test (like ANA IFA or ELISA) is positive.
Differentiation:
To help differentiate between different autoimmune conditions based on the specific antibodies detected.
Important Considerations:
Positive Results:
A positive ANA test result doesn’t necessarily mean you have an autoimmune disease, as many healthy individuals also have ANAs in their blood.
Further Testing:
A positive ANA test often requires further testing to determine the specific type of autoimmune disease and the severity of the condition.
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