The Triple Marker test is a second-trimester prenatal screening test performed between the 14th and 22nd week of pregnancy (ideally 15-20 weeks) to assess the risk of neural tube defects and chromosomal abnormalities, such as Down syndrome and Trisomy 18, in the fetus. It measures levels of three substances in the mother’s blood: Alpha-fetoprotein (AFP), Human chorionic gonadotropin (HCG), and Estriol (uE3). The results, combined with the mother’s age and ultrasound data, are used to calculate the risk for these conditions. A high-risk result indicates the need for further, more invasive, diagnostic tests to confirm the findings.
What the Test Measures
The test analyzes three substances in the mother’s blood:
Alpha-fetoprotein (AFP):A protein the fetus produces; elevated levels can suggest a neural tube defect.
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